منابع مشابه
Models of CaMKII Activation
Models of CaMKII activation Calcium/calmodulin-dependent Kinase Type II (CaMKII) is a Ca-activated enzyme that is highly abundant in the brain. It is central to the regulation of glutamatergic synapses and necessary for the induction of long-term potentiation (LTP), an activity-dependent strengthening of synapses that is thought to be the basis for some forms of learning and memory. CaMKII is a...
متن کاملMechanisms of CaMKII Activation in the Heart
Calcium/calmodulin (Ca(2+)/CaM) dependent protein kinase II (CaMKII) has emerged as a key nodal protein in the regulation of cardiac physiology and pathology. Due to the particularly elegant relationship between the structure and function of the kinase, CaMKII is able to translate a diverse set of signaling events into downstream physiological effects. While CaMKII is typically autoinhibited at...
متن کاملStructural dynamics of troponin during activation of skeletal muscle.
Time-resolved changes in the conformation of troponin in the thin filaments of skeletal muscle were followed during activation in situ by photolysis of caged calcium using bifunctional fluorescent probes in the regulatory and the coiled-coil (IT arm) domains of troponin. Three sequential steps in the activation mechanism were identified. The fastest step (1,100 s(-1)) matches the rate of Ca(2+)...
متن کاملDynamic Kv4.3-CaMKII unit in heart: an intrinsic negative regulator for CaMKII activation.
AIMS Reduction of transient outward current (I(to)) and excessive activation of Ca(2+)/Calmodulin-dependent kinase II (CaMKII) are general features of ventricular myocytes in heart failure. We hypothesize that alterations of I(to) directly regulate CaMKII activation in cardiomyocytes. METHODS AND RESULTS A dynamic coupling of I(to) channel subunit Kv4.3 and inactive CaMKII was discovered in c...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.511